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首页> 外文期刊>British journal of ophthalmology >The change of oxidative stress products in diabetes mellitus and diabetic retinopathy.
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The change of oxidative stress products in diabetes mellitus and diabetic retinopathy.

机译：糖尿病和糖尿病性视网膜病变中氧化应激产物的变化。

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AIM: Enhanced oxidative stress contributes to the pathogenesis of diabetic retinopathy. The aim of this study is to detect oxidative stress parameters in type 2 diabetes mellitus with or without retinopathy and to investigate the relationship between oxidative stress and patients with type 2 diabetic retinopathy. METHODS: Oxidative stress parameters included malondialdehyde (MDA), conjugated diene (CD), advanced oxidation protein products (AOPP), protein carbonyl and 8-hydroxydeoxyguanosin (8-OHdG) in serum measured in 33 patients with diabetes mellitus without complications, 27 diabetes mellitus retinopathy and 32 normal control subjects, respectively. RESULTS: The concentrations of MDA and CD in type 2 diabetes mellitus (DM) were significantly higher than those of the control subjects (p<0.01). The concentration of MDA and CD in patients with retinopathy was significantly elevated in comparison with patients with diabetes without retinopathy (p<0.05). There was a significant increase in serum 8-OHdG in patients with diabetes compared with normal subjects (p<0.01), and serum 8-OHdG was much higher in diabetes mellitus retinopathy than that in patients with diabetes without retinopathy (p<0.05). This was significantly higher in serum AOPP and protein carbonyl in type 2 DM compared with normal subjects (p<0.01). Moreover, diabetes mellitus retinopathy patients had significantly higher AOPP and protein carbonyl compared with patients with diabetes without retinopathy (p<0.05). CONCLUSIONS: These results indicate that there were severe lipid peroxidation, protein oxidation, and oxidative DNA damage in diabetes. The augmented oxidative stress in diabetes may be speculated to contribute to the pathogenesis of diabetes mellitus. Oxidative stress is an important risk factor in the development of diabetic retinopathy. The levels and the types of serum oxidative stress by-products will be in favour of predicting the amount of retinopathy.
机译：目的：增强的氧化应激有助于糖尿病性视网膜病的发病。这项研究的目的是检测2型糖尿病伴或不伴视网膜病变的氧化应激参数，并研究氧化应激与2型糖尿病视网膜病变患者之间的关系。方法：在33例无并发症的糖尿病患者中，血清中的丙二醛（MDA），共轭二烯（CD），高级氧化蛋白产物（AOPP），蛋白羰基和8-羟基脱氧鸟苷（8-OHdG）的氧化应激参数包括视网膜病变和32名正常对照组。结果：2型糖尿病（DM）中MDA和CD的浓度显着高于对照组（p <0.01）。与没有视网膜病变的糖尿病患者相比，视网膜病变患者的MDA和CD浓度显着升高（p <0.05）。与正常受试者相比，糖尿病患者的血清8-OHdG显着增加（p <0.01），并且糖尿病视网膜病变的血清8-OHdG显着高于无视网膜病变的糖尿病患者（p <0.05）。与正常受试者相比，2型糖尿病患者的血清AOPP和羰基蛋白含量显着更高（p <0.01）。此外，与没有视网膜病变的糖尿病患者相比，糖尿病视网膜病变的患者具有更高的AOPP和羰基蛋白（p <0.05）。结论：这些结果表明在糖尿病中存在严重的脂质过氧化，蛋白质氧化和氧化性DNA损伤。可以推测，糖尿病中氧化应激的增加与糖尿病的发病机理有关。氧化应激是糖尿病性视网膜病发展的重要危险因素。血清氧化应激副产物的水平和类型将有利于预测视网膜病变的量。

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