Intravaginal gel prepared from Dead Sea peloid for treating luteal-phase defect.

摘要

Luteal-phase defect is associated with several gynecologic diseases and can be treated with ovulation-inducing agents, proges-terone supplementation, and gonadotropin-releasing hormone agonists [1-3]. It has been recognized that mud applications promote increases in progesterone and estradiol concentrations in women with normal and women with insufficient hormonal functioning of the corpus luteum [4]. Routine intravaginal pelo-therapy involves time-consuming techniques and special facilities. The aim of the present study was to determine the efficacy and relative safety of an intravaginal gel-designed for outpatient use-prepared from Dead Sea peloid in women with luteal-phase defect.