Rectal misoprostol vs. 15-methyl prostaglandin F2alpha for the prevention of postpartum hemorrhage.

摘要

Postpartum hemorrhage (PPH) is a major cause of morbidity and mortality in both developed and developing countries . Various pharmacologic agents, including oxytocin, ergot preparations, and prostaglandin analogues such as 15-methyl prostaglandin F2_alpha and prostaglandin E2, have been found to prevent PPH. However, they are expensive, associated with adverse effects, and require parenteral administration .Misoprostol is a prostaglandin E1 analogue shown in several randomized controlled trials to be effective in preventing PPH because of its strong uterotonic effects [2-4]. Moreover, misoprostol is inexpensive, stable at room temperature, and easy to administer. The present study compared the efficacy and side effects of 400 mug of rectalmisoprostol with 125 mug of 15-methyl prostaglandin F2_alpha in the prevention of PPH.