Choroidal infiltration in juvenile myelomonocytic leukaemia

摘要

Juvenile myelomonocytic leukaemia (JMML), previously called juvenile chronic myelogenous/myeloid leukaemia, is a disorder of infancy and early childhood associated with clonal overproduction of immature myeloid cells, leading to organ infiltration, infection, and failure. Hallmarks include leucocytosis, often with monocytosis, hepa-tosplenomegaly, increased HbF levels, and no Ph chromosome. Allogeneic bone marrow transplant is considered the only curative therapy. Ocular involvement has only been reported on one occasion.