trans-10,cis-12 Conjugated linoleic acid specifically increases tissue alpha-tocopherol mediated by PPAR gamma inhibition in mice

摘要

C57BL/6J mice were divided into control group (C), CLA, c9t11, or t10c12 groups. CLA and t10c12 significantly increased alpha-tocopherol levels in the plasma and various tissues in experiment 1. The CLA and t10c12 groups also showed a significant increase in hepatic alpha-tocopherol transfer protein (alpha-TTP) levels. In experiment 2, mice were divided into control, CLA, R (rosiglitazone, a PPAR gamma agonist), or CLA+ R groups. Vitamin E levels in the liver, epididymal fat pad, kidney, and plasma were increased by CLA, and this effect was reduced in the CLA+ R group. t10, c12-CLA is the most active isomer in the CLA mixture in the regulation of tissue vitamin E status and alpha-TTP protein levels in mice. The increase in liver vitamin E status in CLA-fed mice is mainly due to the effect of PPAR gamma inhibition.