LDL cholesterol-lowering effects of grape extract used as a dietary supplement on healthy volunteers.

摘要

Effects of EminolReg., a polyphenol-rich grape extract supplement, were investigated on cardiovascular risk and oxidant stress indicators. A randomised, double-blind, placebo-controlled clinical trial was performed over 56 days, and included 60 volunteers. 30 volunteers took 700 mg of EminolReg. (E) and 30 took the placebo (P). Comparison of the results showed a decrease in total cholesterol (E: 213.77 +or- 4.1 mg/dl and P: 245.57 +or- 4.1 mg/dl; p = 0.01) and low density lipoprotein (LDL) cholesterol (E: 142.17 +or- 3.1 mg/dl and P: 165.13 +or- 3.1 mg/dl; p = 0.02) levels, as well as an increase in antioxidant capacity (E: 65.63 +or- 5.8 mumol TE/mg and P: 57.80 +or- 7.7 mumol TE/mg; p < 0.01) and vitamin E (E: 11.46 +or- 0.5 mug/ml and P: 9.06 +or- 0.5 mug/ml; p = 0.018). These result indicated that EminolReg. modulated the lipid profile in terms of cardiovascular risk indicators, lowering total blood cholesterol and LDL cholesterol levels.