Effect of pomegranate seed oil on serum TNF- alpha level in dyslipidemic patients.

摘要

Pomegranate punicic acid and fruit extracts have the potential to inhibit tumour necrosis factor- alpha (TNF- alpha) and inflammatory diseases. The aim of this study was to evaluate the effect of pomegranate seed oil (PSO) consumption on serum TNF- alpha level in dyslipidaemic patients. 51 subjects with serum total cholesterol concn. >200 mg/dl and serum triglyceride concn. >150 mg/dl were randomly assigned into PSO (n = 25) and placebo (n = 26) groups. Subjects were given 400 mg PSO or placebo capsules twice daily for 4 wk. 6 patients were excluded because of complications or lack of compliance. Serum TNF- alpha level was measured at baseline and after 4 wk. Mean (s.d.) serum concn. of TNF- alpha decreased from 14.73 +or- 5.25 to 13.28 +or- 3.79 pg/ml in the PSO group (P = NS). Corresponding values in the placebo group were 12.46 +or- 1.67 vs 13.14 +or- 1.67 pg/ml (P = NS). In conclusion, administration of PSO in dyslipidaemic patients did not affect serum TNF- alpha levels.