Dietetic effects of oral intervention with mare's milk on the Severity Scoring of Atopic Dermatitis, on faecal microbiota and on immunological parameters in patients with atopic dermatitis.

摘要

In a double-blind, placebo-controlled crossover trial, 23 patients consumed 250 ml mare's milk or placebo for 16 wks. The aim was to examine the effects of mare's milk on the characteristics of atopic dermatitis (AD), on faecal microbiota and on clinical and immunological parameters. The intensity of AD was examined using the Severity Scoring of Atopic Dermatitis (SCORAD) index. During the mare's milk period, the mean SCORAD value of patients (n = 23; 17 females, 6 males) decreased from 30.1 to 25.3 after 12 wks (P < 0.05) and to 26.7 after 16 wks (P < 0.1). In a subgroup (n = 7) the SCORAD index and especially pruritus decreased by 30% through the mare's milk period (P < 0.01). In this subgroup, faecal bifidobacteria increased during the mare's milk period from 4.6 to 11.9% of eubacteria (P < 0.05). The immunological parameters, except for C-reactive protein, were unchanged.