Higher incidence of retinal pigment epithelium tears after ranibizumab in neovascular age-related macular degeneration with increasing pigment epithelium detachment height

摘要

Tears of the retinal pigment epithelium (RPE) are a well-known complication in patients with pigment epithelium detachment (PED) in occult choroidal neovascu-larisation and may result in loss of vision. They may occur spontaneously or as a complication after various treatments for exudative age-related macular degeneration (AMD). The development of RPE tears during anti-vascular endothelial growth factor (VEGF) therapy for PED in neovascular AMD has been observed in about 12%-17% of treated eyes.The aim of the present study was to investigate whether optical coherence tomography (OCT) findings could provide an estimate of risk for RPE tear development.