One-pot Reaction for the Convenient Synthesis of Functionalized 2-Oxaspirobicyclo2.2.1heptane-2,3 '-indolines

摘要

abstract_textpAn efficient synthetic protocol for functionalized 2-oxaspirobicyclo2.2.1heptane-2,3'-indolines was successfully developed by one-pot two-step reaction of phenacyl bromides, malononitrile and 3-methyleneoxindolines in ethanol in the presence of triethylamine. On the other hand, the similar threecomponent reaction of phenacyl bromides, ethyl cyanoacetate and 3-methyleneoxindolines afforded functionalized spirocyclopentane- 1,3'-indoline derivatives./p/abstract_text