Phase Transfer Catalyst Assisted One-Pot Synthesis of 5-(Chloromethyl)furfural from Biomass-Derived Carbohydrates in a Biphasic Batch Reactor

摘要

abstract_textp5-(Chloromethyl)furfural (CMF), a bio-renewable chemical building block, has been produced in good isolated yields from biomass-derived carbohydrates within a closed aqueous HCl-1,2-dichloroethane biphasic reactor in the presence of benzyltributylammonium chloride (BTBAC) as a phase transfer catalyst (PTC). The solvent-economic, one-pot strategy afforded CMF in 73 isolated yield (90 degrees C, 3 h) from sucrose with a combined yield of 84 for CMF and levulinic acid. The process was optimized on temperature, duration, solvent, type, and loading of PTC. Use of BTBAC led to nearly 10 increase in yield of CMF for all substrates when compared to control reactions./p/abstract_text