IMMUNOMODULATORY IMPACT OF METAMITRON IN BLACK BENGAL GOATS FOLLOWING REPEATED ORAL ADMINISTRATION

摘要

The study was conducted to evaluate immunomodulatory effect of the herbicide, Metamitron in goats .Nine Black Bengal male adult goats were divided into three groups, each containing 3 animals. Control (Gr-I) group received carboxy methyl cellulose, while experimental control (Gr- II) group received levamisole at immunostimulating dose and experimental group (Gr-III) received Metamitron daily for 35 days. On day 36 all goats were immunized with 5% SRBC intraperitoneally. Animals were sacrificed for conducting H a em o lytic Plaque Assay on day 5 post dosing SRBC. Total serum IgG level was estimated by Sandwitch ELISA. No significant variation in serum IgG level was observed at different days against 0 day in control and experimental group. But serumIgG level was increased significantly in experimental control group. No significant variation was observed in percentage of plaque formation in control and experimental group but the value was significantly higher in experimental control group. Results indicated that Metamitron had no effect on immunomodulation of goats during this observation period.