Control issues

摘要

We recently reviewed the article by Killer et al, titled 'Cerebrospinal fluid exchange in the optic nerve in normal-tension glaucoma in our weekly Glaucoma Journal Club at the Bascom Palmer Eye Institute. The article raises the interesting concept that a difference in cerebrospinal fluid (CSF) exchange between the subarachnoid space of the optic nerves and the basal cistern, measured using contrast-enhanced computed cisternography as a marker of ventricular CSF flow, may exist as a contributing factor in the development of normal-tension glaucoma. The authors state, 'All patients -were subjects in another clinical study (Normal Tension and Chronic Open Angle Glaucoma and Cerebrospinal Fluid Composition).' This is an NIH-sponsored study evaluating differences in CSF composition around the optic nerves taken from normal-tension glaucoma patients undergoing optic nerve sheath fenestration with specimens from the same patients undergoing lumbar puncture. The authors recruited 18 subjects and four controls.