Naproxen/esomeprazole magnesium in the treatment of osteoarthritis, rheumatoid arthritis and ankylosing spondylitis

摘要

NSAIDs have been a main stay of arthritis therapy for decades. Some of the adverse events associated with the use of this class of medications include gastrointestinal bleeding, peptic ulcer disease and gastrointestinal symptoms such as dyspepsia and heartburn. Many guidelines exist advising healthcare professionals on how to minimize these risks. Unfortunately, compliance with these guidelines is less than optimal and, even if they are followed by the healthcare professional, patient adherence to this advice is often less than optimal. This article summarizes the published efficacy, safety and patient self-reported outcome results for naproxen/esomeprazole in the treatment of patients with osteoarthritis, rheumatoid arthritis and ankylosing spondylitis.