Synthesis of 3-Substituted Quinazolinones via C-N and C-C bond Cleavage of Enaminone

摘要

A general and efficient TsOH mediated reaction of o-aminobenzamides with enaminone via C-N and C-C bond cleavage leading to quinazolinones has been achieved. This strategy involves C-N/C-C bond cleavage and C-N bond formation in a single operation. Highlight of this work is associated metal free, peroxide free and base free reaction condition. All the synthesized compounds were characterized by NMR and ESIMS spectral studies.