The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.

Khan EU; Reichel A; Begley DJ; Roffey SJ; Jezequel SG; Abbott NJ

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The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.

机译：药物亲脂性对血脑屏障中P-糖蛋白介导的秋水仙碱外排的影响。

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来源
《International journal of clinical pharmacology and therapeutics》 |1998年第2期|共3页
作者
Khan EU; Reichel A; Begley DJ; Roffey SJ; Jezequel SG; Abbott NJ;
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原文格式 PDF
正文语种 eng
中图分类药学;
关键词
Blood-Brain Barrier; Colchicine; Lipids; P-Glycoprotein; Zidovudine; Verapamil; 血脑屏障; 秋水仙碱; 脂类; P-糖蛋白;

机译：Blood-Brain Barrier;Colchicine;Lipids;P-Glycoprotein;Zidovudine;Verapamil;血脑屏障;秋水仙碱;脂类;P-糖蛋白;

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专利

1. The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier. [J] . Khan EU, Reichel A, Begley DJ, International journal of clinical pharmacology and therapeutics . 1998,第2期

机译：药物亲脂性对血脑屏障中P-糖蛋白介导的秋水仙碱外排的影响。
2. Transporter-based delivery of anticancer drugs to the brain: improving brain penetration by minimizing drug efflux at the blood-brain barrier. [J] . Ngoc H On, Donald W Miller Current pharmaceutical design . 2014,第10期

机译：基于转运蛋白的抗癌药物向大脑的输送：通过最小化血脑屏障的药物外流来提高大脑的渗透性。
3. High brain distribution of a new central nervous system drug candidate despite its P-glycoprotein-mediated efflux at the mouse blood-brain barrier [J] . Taccola Camille, Cartot-Cotton Sylvaine, Valente Delphine, European journal of pharmaceutical sciences . 2018,第期

机译：尽管其p-糖蛋白介导的小鼠血脑屏障介导的新的中枢神经系统药物候选者的高脑分布
4. A Novel Canine-Specific Model System to Study Intestinal P-Glycoprotein-Mediated Drug Transport [C] . American College of Veterinary Internal Medicine Forum Conference . 2019

机译：一种研究肠道糖蛋白介导的药物运输的新型犬特异性模型系统
5. Nanoparticles as drug carriers across the blood-brain barrier. [D] . Koziara, Joanna M. 2005

机译：纳米颗粒作为跨血脑屏障的药物载体。
6. Drug Points: Tetraparesis associated with colchicine is probably due to inhibition by verapamil of the P-glycoprotein efflux pump in the blood-brain barrier [O] . Uwe Tröger, Hartmut Lins, Jean-M Scherrmann, 2005

机译：药物要点：与秋水仙碱有关的四肢瘫痪可能是由于维拉帕米抑制了血脑屏障中的P-糖蛋白外排泵
7. Expression of tight junction and drug efflux transporter proteins in an in vitro model of human blood-brain barrier. [O] . CIONI C., TURLIZZI E., ZANELLI U., 2012

机译：紧密连接和药物外排转运蛋白在人血脑屏障体外模型中的表达。

The effect of drug lipophilicity on P-glycoprotein-mediated colchicine efflux at the blood-brain barrier.

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