Acid-Catalyzed Four-Component Tandem Double Cyclization: Access to Dihydroindolizino8,7-bindoles

摘要

abstract_textpThe novel one pot four-component reaction for the construction of dihydroindolizino8,7-bindoles and their derivatives have been developed from ninhydrine, tryptamine, dimetylene acetylene dicarboxylate and aliphatic alcohol. This reaction produces to go through via Pictet-Spengler cyclization reaction and construction of C-C and C-N bond readily achieved under transition metal free condition. Meanwhile, advantageous of tandem double cyclization are not only reducing reaction steps but also waste production./p/abstract_text