Influence of Selenium‐Supplemented Torula Yeast Diets on Liver‐Mediated Mutagenicity of Aflatoxin B1

摘要

ABSTRACTTo determine the effect of dietary selenium on the mutagenicity of aflatoxin B1(AFB1), male Sprague‐Dawley rats were fed rat chow or Torula yeast diets supplemented with 0.0, 0.1, 0.5, 1.0, and 5.0 ppm Se as Na2SeO3, and the 9000 ×gliver supernatants were used inSalmonella/microsome mutagenesis assays. The rats were fed on the diets for 4 wk and, prior to killing, half the rats in each group received 80 mg phenobarbital/kg body weight in their drinking water for four consecutive days. Phenobarbital administration tended to increase the mutagenicity of AFB1in all dietary treatment groups. This increase was significant only in the chow‐fed groups, however. Addition of selenium to the basal diet produced no significant effect on liver‐mediated mutagenicity. The liver preparation from chow‐fed animals which had received phenobarbital produced the highest mutagenicity of the sample