Drug prescribing in patients with renal impairment optimized by a computer-based, semi-automated system

摘要

Background According to several studies, despite of the existence of several published guidelines for dosing adjustments based on renal function, inappropriate prescribing is a common drug-related problem in inpatient care. Objective We developed and implemented a system for drug dosage adjustment integrated into the Hospital computer provider order entry system. This system allows pharmacists to identify patients with reduced renal function, identify medication orders that may require dosage modifications based on renal function, and generate an alert with a recommendation of specific dosage adjustment. Using the Summary of Product Characteristics and two drug databases (Micromedex 2.0? and Lexicomp?), specific dosage guidelines for drugs used in patients with renal impairment were established. Setting A 264-bed tertiary teaching hospital. Methods We performed a quasi-experimental, one-group, pretest-posttest study to assess the efficacy of this intervention program. We compared the differences between the frequency of appropriate orders pre- and post-test using the McNemar test. Main outcome measures: the frequency of appropriate orders before the recommendation (pre-test) and after the recommendation (post-test).