Fibrin beta(15-42) domain is cryptic in intact fibrinogen: comment on the study by A. Sahni et al.

摘要

With interest we read the article by Abha Sahni and co-workers; "The VE-cadherin binding domain of fibrinogen induces endothelial barrier permeability and enhances trans-endothelial migration of malignant breast epithelial cells" in the edition of August 1st, 2009.: Sahni et al. showed that addition of intact fibrinogen induces an increase in endothelial permeability. This increase was shown to be mediated via binding of fibrinogen domain beta to VE-cadherin on endothelial cells. Transendothelial migration of malignant breast cancer cells was increased by fibrinogen. The data provide novel insight in transendothelial migration of malignant cells, which require fibrinogen domain beta and VE-cadherin binding.