Trends in Outcomes and Hospitalization Charges among Mechanically Ventilated Patients with Myasthenia Gravis in the United States

摘要

Introduction: To assess the impact of new therapeutic strategies on outcome and cost of hospitalizationamong patients with myasthenia gravis (MG) who are mechanically ventilated in United States. Methods:Using a retrospective analysis of cross sectional survey, we determined the rates of occurrence, in-hospitaloutcomes, and mean hospital charges for patients hospitalized with MG requiring mechanical ventilationin 1991-1992 using the Nationwide Inpatient Survey (NIS) and compared these outcomes with homologousdata from 2001-2002. NIS is the largest all-payer inpatient care database in the United States. Results: Whencomparing data from 2001-2002 with data from 1991-1992, we found a higher number of admissions for MGthat required mechanical ventilation (994 vs. 652). The proportion of women was similar (53% vs. 60%).The average age (in years ± standard deviation) was significantly higher (65 ± 17 vs. 58 ± 18, p=0.0002). Thelength of hospitalization (in days ± standard deviation) was not different (22 ± 19 vs. 21 ± 16). Discharge tohome occurred less frequently (29% vs. 60%, p=0.0001) and in hospital mortality minimally lower (13%vs. 15%). There was a significant increase in mean hospital charges (