Comparative In Vitro Osteoinductivity Study of HA and alpha-TCP/HA Bicalcium Phosphate

摘要

A bicalcium phosphate (BCP) bioceramic comprising alpha-tricalcium phosphate (alpha-TCP) and hydroxyapatite (HA) was prepared by a two-step sintering. The microstructure of the BCP bioceramic was investigated using scanning electron microscopy (SEM), transmission electron microscopy (TEM), and X-ray diffraction. The in vitro osteoinductivity was evaluated by culturing MG63 osteoblast-like cells on the BCP bioceramic. Results showed that the BCP bioceramic comprising alpha-TCP and HA in a moderate ratio possessed a hardness of 93.7 Hv. The cells spread faster on the BCP bioceramic than those on the commercial HA. It suggested that the BCP bioceramic can enhance osteoinductivity in vivo.