Contribution of the Centrifugal Partition Chromatography (CPC) to the Purification of Zincke Reaction Products

摘要

abstract_textpThe Zincke reaction poses a difficulty when attempting to purify the crude mixtures and isolate reaction products in analytically pure form. This paper introduces the successful method of using the centrifugal partition chromatography (CPC) to isolate pyridinium salts garnered by this reaction returning good yields and high degrees of purity. Efficient purifications were obtained by using (n-BuOH/MeOH/H2O) biphasic solvent systems. The CPC confirmed its suitability for isolating compounds prone to decompose during purification on solid stationary phases. It has also proved to be an efficient method for valorizing incomplete Zincke reactions./p/abstract_text