Effect of high-dose fluconazole on QT interval in patients with human immunodeficiency virus (HIV)-associated cryptococcal meningitis

摘要

Azoles may cause prolongation of the QT interval either directly or by inhibiting the hepatic metabolism of other QT-prolonging agents [1,2]. Ketoconazole is known to block the human ether-a-gogo- related gene (hERG) product and thereby inhibit the potassium IKr current in the heart [3].Whether fluconazole also inhibits hERG is currently unknown.