Standardization of pahrmacokinetic/pharmacodynamic (PK/PD) terminology for anti-infective drugs

摘要

Over the last decades, the interest in the relationships between the pharmacokinetics (PK) and pharmacodynamics (PD) of antimicrobial agents has increased and, therefore, the use of PK/PD indices and expressions has spread widely. The appropriate definition and use of these parameters is a matter of controversy. This paper contains a proposal to use PK/PD expressions for antimicrobial agents and their units in a uniform manner. (C) 2002 Published by Elsevier Science B.V. and International Society of Chemotherapy. [References: 11]