Synthesis of 3-(3,5-Dimethyl-2-(1,8-Naphthyridin-7- Yl)Phenyl)-1,3,5-Triazinan-2-Ones and 3-(3,5- Dimethyl-2-(1,8-Naphthyridin-7-Yl)Phenyl)-1,3,5- Oxadiazinan-4-Ones as Antibacterial Agents

摘要

3,5-Dimethyl-2-(1,8-naphthyridin-7-yl)benzenamine (1) reacts with isocyanates to form 1-(3,5-dimethyl-2-(1,8-naphthyridin-7-yl)phenyl)ureas (2a-e). Compound (2a-e) are converted to different 3-(3,5-dimethyl-2-(1,8-naphthyridin-7-yl)phenyl)-1,3,5-triazinan-2-ones (3a-j) by the reaction of urea derivatives (2a-e) and amines in EtOH in presence of TEA. Oxadiazinan-4-ones (4a-e) are obtained by the reaction of (2a-e) and formaldehyde in EtOH. Urea derivatives (2a-e) are also converted to isocyanates (5a) by treating 2a-e with triphosgene in DCM.