'One-Pot' Selective Synthesis of 3,4-Disubstituted Pyrroles and Benzofindole-4,9-diones from 1,3-Indanedione, Aromatic Aldehydes and TosMIC

摘要

abstract_textpA variety of 3,4-disubstituted pyrroles and benzofindole-4,9-diones have been selectively synthesized from readily available aromatic aldehydes, 1,3-Indanedione and tosylmethyl isocyanide (TosMIC) by a one-pot procedure in high yields. This methodology features operationally simple, practical with broad substrate scope and usage of easy to handle reagents. The one-pot sequential reactions proposed to proceeds through a tandem insitu generated chalcones and 3 + 2-cycloaddition/ring cleavage or expansion process./p/abstract_text