Soluble ICAM‐1 as a regulator of nasal allergic reaction under natural allergen provocation

摘要

Background:Intercellular adhesion molecule‐1 (ICAM‐1) plays a key role in the early stage of the signal cascade leading to cellular extravasation and the development of an inflammatory response. Recently, it has been reported that the soluble form of this adhesion molecule is present in human sera, possibly mediating biological actions.Objective:The purpose of this study was to investigate levels of soluble ICAM‐1 (sICAM‐1) and its receptors in patients with allergic rhinitis, and to discuss sICAM‐1's biological function.Methods:The levels of sICAM‐1 in sera and nasal epithelial lining fluids (ELF), the percentage of CD11a‐positive lymphocytes in the peripheral blood, and scores of subjective symptoms from 14 patients with pollinosis (allergic group) were measured from pre‐ to post‐season, results were compared with those from 10 non‐allergic subjects (control group).Results:The levels of sICAM‐1 in sera and ELF were upregulated, and CD11a‐positive lymphocytes were downregulatcd during the in‐season in the allergic group. In addition, levels of sICAM‐1 in sera from the allergic group remained high during the post‐season, when levels of other parameters (symptoms, blood eosinophil counts, sICAM‐1 in ELF and CD11a‐positive lymphocytes) had roughly returned to the initial pre‐season levels.Conclusions:We demonstrate systemic and local upregulation of sICAM‐1 and systemic downregulation of LFA‐1 positive lymphocytes in patients with seasonal allergic rhinitis under natural allergen provocation, suggesting that sICAM‐1 plays a role in