NIP AND TUCK AT THE NEUROMUSCULAR JUNCTION - A ROLE FOR PROTEASES IN DEVELOPMENTAL SYNAPSE ELIMINATION

摘要

During late embryonic and early postnatal development, synaptic connections are extensively modified so that some functional connections are weakened and eliminated from a neural circuit while others are strengthened and maintained. The mechanisms that underlie synapse elimination are beginning to be understood from studies of the neuromuscular junction. A recent paper((1)) provides some intriguing insights into the role proteases may play in the developmental disassembly of neuromuscular synapses. References: 32