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Baicalein attenuates inflammatory responses by suppressing TLR4 mediated NF-kappa B and MAPK signaling pathways in LPS-induced mastitis in mice

机译:黄ical素通过抑制LPS诱导的乳腺炎小鼠中TLR4介导的NF-κB和MAPK信号通路来减轻炎症反应

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摘要

Baicalein is a phenolic flavonoid presented in the dry roots of Scutellaria baicalensis Georgi. It has been reported that baicalein possesses a number of biological properties, such 8 antiviral, antioxidative, anti-inflammatory, antithrombotic, and anticancer properties. However, the effect of baicalein on mastitis has not yet been reported. This research aims to detect the effect of baicalein on lipopolysaccharide (LPS)-induced mastitis in mice and to investigate the molecular mechanisms. Baicalein was administered intraperitoneally 1 h before and 12 h after LPS treatment. The results indicated that baicalein treatment markedly attenuated the damage of the mammary gland induced by LPS, suppressed the activity of myeloperoxidase (MPO) and the levels of tumor necrosis factor (TNF-alpha) and interleukin (IL-1 beta) in mice with LPS-induced mastitis. Besides, baicalein blocked the expression of Toll-like receptor 4 (TLR4) and then suppressed the phosphorylation of nuclear transcription factor-kappaB (NF-kappa B) p65 and degradation inhibitor of NF-kappa B alpha (I kappa B alpha) and, and inhibited the phosphowlation of p38, extracellular signal-regulated kinase (ERIC) and c-jun NH2-terminal kinase (JNK) in mitogen-activated protein kinase (MAPK) signal pathway. These findings suggested that baicalein may have a potential prospect against mastitis. (C) 2015 Elsevier B.V. All rights reserved.
机译:黄ical素是存在于黄cut干根中的一种酚类黄酮。据报道黄ba素具有许多生物学特性,例如8种抗病毒,抗氧化,抗炎,抗血栓形成和抗癌特性。然而,尚未报道黄ical素对乳腺炎的作用。本研究旨在检测黄ical素对脂多糖(LPS)诱导的小鼠乳腺炎的作用,并研究其分子机制。在LPS治疗前1小时和治疗后12小时腹膜内施用黄ical素。结果表明,黄ical素处理可显着减轻LPS引起的乳腺损伤,抑制髓过氧化物酶(MPO)的活性以及LPS小鼠的肿瘤坏死因子(TNF-alpha)和白介素(IL-1 beta)的水平诱发的乳腺炎。此外,黄ical素会阻断Toll样受体4(TLR4)的表达,然后抑制核转录因子-κB(NF-kappa B)p65和NF-kappa B alpha(I kappa B alpha)降解抑制剂的磷酸化,并且并抑制有丝分裂原激活的蛋白激酶(MAPK)信号通路中的p38,细胞外信号调节激酶(ERIC)和c-jun NH2末端激酶(JNK)的磷酸化。这些发现表明黄ical素可能具有治疗乳腺炎的潜在前景。 (C)2015 Elsevier B.V.保留所有权利。

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