Female C57BL/6J mice lacking the circadian clock protein PERI are protected from nondipping hypertension

摘要

The circadian clock is integral to the maintenance of daily rhythms of many physiological outputs, including blood pressure. Our laboratory has previously demonstrated the importance of the clock protein period 1 (PERI) in blood pressure regulation in male mice. Briefly, a high-salt diet (HS; 4 NaCl) plus injection with the long-acting mineralocor-ticoid deoxycorticosterone pivalate (DOCP) resulted in nondipping hypertension <10 difference between night and day blood pressure (BP) in Per1-knockout (KO) mice but not in wild-type (WT) mice.