Synthesis and antioxidant activities of some novel fluorinated spirooxindole-thiazolidine fused with sulfur and phosphorus heterocycles

摘要

Facile routes were achieved for the synthesis of novel fluorinated spirooxindole-thiazolidinone fused with some sulfur and phosphorus heterocycles starting from 5-fluoro-3'-(4-fluorophenyl)-4H-spiroindole-3,2'-thiazolidine-2,4'(1H)-dione (1) via its reaction with trifluoroacetamide, 2-chloro-6-fluorobenzaldehyde and hydrazine hydrate followed by treatment with some suitable sulfur and phosphorus reagents. The antioxidant activities of the synthesized compounds were also evaluated.