Foxp3 gene polymorphisms and haplotypes associate with susceptibility of Graves' disease in Chinese Han population

摘要

Background: Foxp3 plays important roles in the pathogenesis of autoimmune diseases. To investigate the association between Foxp3 gene polymorphisms and the susceptibility to Graves' disease (GD) in Chinese Han population, four single nucleotide polymorphisms (SNPs) including -2383, -3279, -3499 in the promoter and IVS9 + 459 in the intron were genotyped.