Biocide resistance mechanisms

摘要

Information about the mechanisms of action and resistance of biocides used as preservatives, sanitizers, and disinfectants continues to accumulate. While biocides are generally not as well-studied as antibiotics, it is becoming clear that bacteria employ the same major resistance strategies against both groups of antibacterial chemicals. The resistance strategies-inhibitor inactivation, target site alteration, and target site exclusion-are described in the context of the presumed mechanisms of action of the biocides using examples drawn from the literature.