Decorated Peptide Nanofibers with Cu Nanoparticles: An Efficient Catalyst for the Multicomponent Synthesis of Chromeno 2, 3-d pyrimidin-8-amines, Quinazolines and 2H-Indazoles

摘要

abstract_textpAn efficient, simple and green protocol has been developed for the synthesis of 7, 10-diaryl-7Hbenzo 7, 8 chromeno2,3-d pyrimidin-8-amine, 2H-indazole and quinazoline derivatives in the presence of decorated peptide nanofibers with Cu nano-particles. Peptide nanofibre has been synthesised by self-assembly technique. In this work, the effect of succinic anhydride was evaluated in two conditions: i) without adding succinic anhydride at pH 4, ii) by adding succinic anhydride at pH 5. Synthesized peptide nanofiber was characterized by H-1,C-13, DEPTNMR spectroscopies (Distortionless enhancement by polarization transfer), CHNSO, scanning electron microscopy (SEM), fluorescence spectroscopy, UV/Vis, FTIR and transmission electron microscopy (TEM)./p/abstract_text