High risk of 'de novo' acute myeloid leukaemia in individuals with cytochrome P450 A1 (CYP1A1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) gene defects.

摘要

The environmental exposure to benzene and tobacco's polycyclic aromatic hydrocarbons (PAH) has been associated with an increased risk for acute myeloid leukaemia (AML). The ability to metabolise carcinogens varies among human beings and, therefore, healthy individuals may be at distinct risks of the disease.