Biological monitoring and the influence of genetic polymorphism of As3MT and GSTs on distribution of urinary arsenic species in occupational exposure workers

摘要

To examine the differences in urinary arsenic metabolism patterns in men affected by occupational exposure, we performed a study on 149 participants-workers of a copper mill and 52 healthy controls without occupational exposure. To elucidate the role of genetic factors in arsenic (As) metabolism, we studied the associations of six polymorphisms: As3MT Met287Thr (T > C) in exon 9; As3MT A > G in 5'UTR; As3MT C > G in intron 6; As3MT T > G in intron 1; GSTP1 Ile105Val and GSTO2 T > C.