Downregulation of GATA6 in mTOR-inhibited human aortic endothelial cells: effects on TNF-a-induced VCAM-1 expression and monocytic cell adhesion

摘要

Increased expression of vascular cell adhesion molecule 1 (VCAM-1) on the aortic endothelium is an early marker of atherogenesis, promoted in part by elevated levels of inflammatory cytokines such as TNF-alpha. Mammalian target of rapa-mycin (mTOR) is a ubiquitous signaling molecule that has been considered to contribute to diverse cellular processes through mTOR complex 1 (mTORC1) or complex 2 (mTORC2).