Synthesis, mechanism of action, and QSAR of herbicidal 3‐substituted‐2‐aryl‐4,5,6,7‐tetrahydroindazoles

摘要

AbstractA factorially designed set of 3‐substituted 2‐aryl‐4,5,6,7‐tetrahydroindazoles was synthesized and their herbicidal properties were evaluated using regression analysis. For optimal activity, the substituent at position 3 should be neither strongly hydrophobic nor hydrophilic and should have a small minimum radius. A study of the mechanism of action indicated that the tetrahydroindazoles are inhibitors of the enzyme protoporphyrinogen