HDInsight4PSi: Boosting performance of 3D protein structure similarity searching with HDInsight clusters in Microsoft Azure cloud

摘要

3D protein structure similarity searching is one of the important processes performed in structural bioinformatics, since it allows for protein function identification and reconstruction of phylogeny for weakly related organisms. Due to the complexity of 3D protein structures and exponential growth of protein structures in public repositories, like the Protein Data Bank, the process is time-consuming and requires increased computational resources. This causes the necessity to prepare computer systems to be able to deal with such huge volumes of macromolecular data.