Pharmacokinetics of urea: Development of a kinetic model for correlating dietary nitrogen intake and urea metabolism in chronic renal failure

摘要

AbstractA simple urea pharmacokinetic model is developed to define the multiple correlations among dietary nitrogen intake, urea generation rate, and serum urea nitrogen. Model‐based patient data are simulated during and between dialysis for serum urea nitrogen. Application of the kinetic model is demonstrated by retrospective fitting of serum urea nitrogen to the simultaneous equations which pertain to the model. The pharmacokinetic parameters obtained through the computer fitting can be integrated according to the mass balance equation to yield a quantitative solution to achieving the regulation of protein nitrogen intake. The kinetic approach is potentially advantageous over the conventional nitrogen balance method by virtue of its simplicity. Further validation of the pharmacokinetic model is required before its clinical applicatio