Nontoxic concentration of amphotericin B for intravitreal use — evaluated by in vitro ERG

摘要

Amphotericin B (AMPH)-induced changes of the electroretinogram (ERG) were studied in the in vitro eye-cup of the albino rabbit. The a-wave, b-wave, oscillatory potentials and c-wave were not changed by 1 μM AMPH, and these all were slightly suppressed by 5 μM AMPH. These changes were mostly reversible. The b-wave and oscillatory potentials were greatly suppressed by 50 μM AMPH. These changes were only partially reversible 75 minutes after re-perfusion without AM