Despite the large interest of research and clinical investigators in acute stroke, for years this subject has been regarded and treated exclusively as a grey matter disease, and the focus of research has almost entirely been on neu-ronal compartment. This approach might have resulted in a limited understanding of the physiopathology of acute stroke and, possibly, contributed to the ensuing failure in finding neuroprotective strategies able to reduce the ischemic damage to the brain parenchyma.
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