Increased serotonin receptor 1A binding in major depressive disorder after psychotherapy, but not after SSRI pharmacotherapy, is related to improved social functioning capacity

摘要

Recovery from depression after treatment with medication does not increase the density of 5-hydroxytryptamine receptors 1A (5-HT1A), even after a long unmedicated period 1, and there is no correlation between the 5-HT1A binding potential (BP) and the severity of depression symptoms 2. This has led to the conclusion that the lower level of 5-HT1A receptors could be a trait marker of depression, reflecting a heightened risk for further depressive episodes.