Eine einfache Synthese aller vier stereoisomeren 2,2,5-Trimethyl-1,3-dioxolan-4-carbaldehyde

摘要

A simple and efficient procedure for the syntheses of all four stereoisomers of the 2,2,5-trimethyl-1,3-dioxolane-4-carbaldehydes1a–1dhas been developed. Starting with readily available aldopentose diethyl dithioacetals2,6,10and14, the title compounds were obtained by a selective protecting group strategy and subsequentRaney-nickel reduction, followed by lead tetraacetate cleavage. This procedure allows an application on a multigram scal