SERUM AND URINARY CONCENTRATION OF PEFLOXACIN IN CATTLE FOLLOWING A SINGLE INTRAMUSCULAR DOSE

摘要

The concentration of pefloxacine in serum and urine of bullocks was determined at different time intervals, following its single i/m injection @ 5 mg/kg. The peak serum concentration of pefloxacin was achieved within 30 min with detectable concentration upto 48 hr of post- injection. The antibiotic appeared in urine within 5 min with peak concentration at 30 min of post injection. Pefloxacin could not be detected in urine at 120 hr of post administration. These observations indicated rapid absorption and persistence of pefloxacin and its meagre renal excretion following injection in bullocks.