Disseminated intravascular coagulation in the presence of antiphospholipid antibodies: The differential diagnosis from catastrophic or microangiopathic antiphospholipid syndrome

摘要

Disseminated intravascular coagulation (DIC) is characterizedby widespread activation of coagulation that results inthrombotic occlusion of small- and mid-sized vessels. Simultaneously,the consumption of coagulation factors andplatelets and the activation of fibrinolysis provoke paradoxicalhemorrhage (1, 2). Antiphospholipid syndrome (APS) isan autoimmune disorder characterized by arterial/venousthrombosis and pregnancy morbidity that is associated withthe presence of autoantibodies against phospholipid bindingproteins represented by ?2-glycoprotein I (?2GPI) andprothrombin.