首页>
外文期刊>Pesticide science
>Factors governing the toxicity of putative synaptic transmitters and their analogues when injected into the haemocoel of adult maleLucilia sericata
【24h】
Factors governing the toxicity of putative synaptic transmitters and their analogues when injected into the haemocoel of adult maleLucilia sericata
AbstractAcetylocholine, arecoline, 2‐(dimethylamino)ethyl acetate, L‐glutamic acid, L‐4‐methyl‐eneglutamic acid, (±)‐quisqualic acid, 4‐aminobutyric acid, and dicrotophos were injected into the haemocoel of adult male Lucilia sericata. Large doses of the putative transmitters and their analogues were required for toxicity. The water soluble organo‐phosphate dicrotophos was much more toxic than any of the other compounds. Electrophysiological experiments indicated that the putative transmitters were reaching their presumed site of action in the nervous system and that their toxicity could be correlated with the intensity and duration of their effect at this site. Biochemical measurements of the rate of loss of the putative transmitters from the haemolymph indicate that, in vivo, the test insect possesses efficient mechanisms for removing these compounds from the system being studied. It is concluded that the low toxicity of the putative transmitters, which are presumed to interact reversibly with post synaptic receptor sites, may be largely due to their rapid removal from the system, resulting in a rapid fall in concentration at t
展开▼
机译:摘要将乙酰胆碱、槟榔碱、2-(二甲氨基)乙酸乙酯、L-谷氨酸、L-4-甲基-谷氨酸、(±)-喹喹酸、4-氨基丁酸和双氯磷注射到成年雄性蒺鲷的血腔中。毒性需要大剂量的推定递质及其类似物。水溶性有机磷酸二氯磷的毒性比任何其他化合物都大得多。电生理学实验表明,假定的递质正在到达其在神经系统中假定的作用部位,并且它们的毒性可能与其在该部位的作用强度和持续时间相关。对血淋巴中假定递质损失率的生化测量表明,在体内,测试昆虫具有从所研究系统中去除这些化合物的有效机制。得出的结论是,推定的递质的低毒性,其被认为与突触后受体位点可逆地相互作用,可能主要是由于它们迅速从系统中移除,导致浓度在 t
展开▼