Multidrug-resistant Acinetobacter: a threat to the antibiotic era.

摘要

Multidrug-resistant Acinetobacter has now emerged as an impressive organism, with unique skills of adaptation that will allow it to persist as a problem well into the future. The epidemiology of this organism is complex and emphasizes the importance of use of molecular tools in outbreak investigation. The challenges of antimicrobial treatment are mounting and have led clinicians to seek older or non-traditional agents in an attempt to maximize patient outcomes. Our ability to differentiate colonization from infection is of critical importance, especially for respiratory samples, as inappropriate antibiotic use will only add fuel to an already raging fire. Future research should be targeted towards the most effective strategies to prevent the spread of multidrug-resistant Acinetobacter, as well as, new or novel therapeutics for the treatment of highly resistant Gram-negative bacilli, including Acinetobacter.