ADVERSE EFFECTS OF THE AMINOSALICYLATES

摘要

The aminosalicylate group of drugs, used in the treatment of inflammatory bowel disease, has a variety of adverse effects, which include:Common adverse reactionsNausea, vomiting, abdominal pain mdash; Up to 40percnt; with sulphasalazine; much less with mesalazine or olsalazineHeadache mdash; 1ndash;15percnt; with sulphasalazine; less with mesalazine or olsalazineBlood dyscrasias mdash; 1ndash;3percnt; with sulphasalazine Rare with mesalazine or olsalazine.Male intertility mdash; 80percnt; with sulphasalazine, None with mesalazine or alsalazine.Watery diarrhoea mdash; All 5-ASA preparations; obout 15percnt; with olsalazine.Rash fever mdash; 0.5ndash;5percnt; with sulphasalazine; rare with mesalazine or olsalazine.Rare adverse reactionsNephrotoxicity mdash; All drugs. Possibly more common with mesalazine.Pancreatitis mdash; Possibly more common with mesalazine.Exacerbation of coiltis, hepatotoxicity, pulmonary fibrosis, polyarteritis mdash; Very rare with a ninosalicylates.